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We use despite in one half of a sentence to make the rest of the
sentence surprising.
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despite something
despite + -ing
despite the fact that
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Despite the heavy traffic, we got there on time.
Despite being much older than the others, he won the race.
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In spite of has the same meaning as despite.
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in spite of something
in spite of + -ing
in spite of the fact that
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In spite of the heavy traffic, we got there on time.
In spite of the fact that he is much older than the others, he
won the race.
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We prefer despite to in spite of in written English.
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